abstract：:CD163, a monocyte and macrophage-specific surface glycoprotein, which is increased by interleukin-10 and glucocorticoids, is a scavenger receptor for hemoglobin/haptoglobin complexes. We report a rapid and highly reproducible rise in soluble CD163 in the plasma of human volunteers given intravenous lipopolysaccharide ...

journal_title：Journal of leukocyte biology

authors： Hintz KA,Rassias AJ,Wardwell K,Moss ML,Morganelli PM,Pioli PA,Givan AL,Wallace PK,Yeager MP,Guyre PM

更新日期：2002-10-01 00:00:00

abstract：:Alzheimer's disease (AD) is a progressive, neurodegenerative disease characterized by the presence of multiple senile plaques in the brain tissue, which are also associated with considerable inflammatory infiltrates. Although the precise mechanisms of the pathogenesis of AD remain to be determined, the overproduction ...

journal_title：Journal of leukocyte biology

authors： Cui Y,Le Y,Yazawa H,Gong W,Wang JM

更新日期：2002-10-01 00:00:00

abstract：:Recombinant fusion proteins consisting of the extracellular domain of immunoregulatory proteins and the constant domain of immunoglobulin G (IgG) are a novel class of human therapeutics. IgG isoforms exert different levels of immune effector functions, such as complement lysis and antibody-dependent cell cytotoxicity ...

journal_title：Journal of leukocyte biology

authors： Taylor L,Bachler M,Duncan I,Keen S,Fallon R,Mair C,McDonald TT,Schwarz H

更新日期：2002-09-01 00:00:00

abstract：:Lymphocyte development is initiated from hematopoietic stem cells and can be divided into multiple phenotypically distinct stages. Transcription factors play important roles in programming the developmental process of lymphocytes. Recent studies have identified key roles of several orphan nuclear receptors in T lympho...

journal_title：Journal of leukocyte biology

authors： He YW

更新日期：2002-09-01 00:00:00

abstract：:Workshop cluster 1 (WC1) is a member of the scavenger receptor cysteine-rich (SRCR) superfamily that includes CD5, CD6, CD163, and M160. Bovine WC1 consists of 11 SRCR domains, a unique domain 1, and two homologous 5 SRCR domain cassettes, WC1 domains 2-6 and 7-11. The porcine orthologue of WC1 contains five SRCR doma...

journal_title：Journal of leukocyte biology

authors： Ahn JS,Konno A,Gebe JA,Aruffo A,Hamilton MJ,Park YH,Davis WC

更新日期：2002-08-01 00:00:00

abstract：:We compared the effects of live or inactivated bovine respiratory syncytial virus (BRSV) on cytokine production by bovine monocyte-derived dendritic cells (MoDC). We also investigated the response of resting memory CD4(+) T cells to MoDC exposed to both viral preparations. Although BRSV did not appear to replicate in ...

journal_title：Journal of leukocyte biology

authors： Werling D,Collins RA,Taylor G,Howard CJ

更新日期：2002-08-01 00:00:00

abstract：:Cytokines and chemokines play an essential role in recruiting leukocytes from the circulation to the peripheral sites of inflammation by modulating cellular interactions with endothelial cell ligands and extracellular matrix (ECM). Herein, we examined regulation of T cell adhesion to ECM ligands by two major proinflam...

journal_title：Journal of leukocyte biology

authors： Ariel A,Novick D,Rubinstein M,Dinarello CA,Lider O,Hershkoviz R

更新日期：2002-07-01 00:00:00

abstract：:Live, but not dead Bacillus Calmette-Guérin (BCG) is partially protective against infection by Mycobacterium tuberculosis, which causes a disease with high mortality in immune compromised individuals. We have shown that uptake of BCG induces maturation of immature dendritic cells (DCs) regardless of the viability of t...

journal_title：Journal of leukocyte biology

authors： Tsunetsugu-Yokota Y,Tamura H,Tachibana M,Ogata K,Honda M,Takemori T

更新日期：2002-07-01 00:00:00

abstract：:CD137, a member of the TNF receptor family, and its ligand are expressed on T lymphocytes and antigen-presenting cells (APC), respectively. During interaction with APC, T lymphocytes receive a potent, costimulatory signal through CD137. Reverse signaling has been demonstrated for the CD137 ligand, which causes activat...

journal_title：Journal of leukocyte biology

authors： Pauly S,Broll K,Wittmann M,Giegerich G,Schwarz H

更新日期：2002-07-01 00:00:00

abstract：:Eosinophil migration from circulation is controlled, in part, by chemokines through a family of G-protein-coupled chemokine receptors (CCR). Studies of human eosinophils have demonstrated that signaling through CCR3 receptors is a prominent pathway leading to chemotaxis, although several other receptor-ligand interact...

journal_title：Journal of leukocyte biology

authors： Borchers MT,Ansay T,DeSalle R,Daugherty BL,Shen H,Metzger M,Lee NA,Lee JJ

更新日期：2002-06-01 00:00:00

abstract：:In this study, we have investigated the expression of phospholipase C-beta2 during the course of granulocytic differentiation of normal and malignant progenitors. As a model system, we used the NB4 cell line, a reliable in vitro model for the study of acute promyelocytic leukemia (APL), a variety of acute myeloid leuk...

journal_title：Journal of leukocyte biology

authors： Bertagnolo V,Marchisio M,Pierpaoli S,Colamussi ML,Brugnoli F,Visani G,Zauli G,Capitani S

更新日期：2002-06-01 00:00:00

abstract：:In this study, we analyzed the specific effects of transforming growth factor beta (TGF-beta1) and/or IL-4 on monocyte-derived cells. Monocytes were cultured with GM-CSF, GM-CSF/TGF-beta1, GM-CSF/IL-4, or GM-CSF/IL-4/TGF-beta1 before cell morphology, phenotype, and function were assessed. As expected, interleukin-4 is...

journal_title：Journal of leukocyte biology

authors： Guironnet G,Dezutter-Dambuyant C,Vincent C,Bechetoille N,Schmitt D,Péguet-Navarro J

更新日期：2002-05-01 00:00:00

abstract：:The neutrophil inflammatory response can be altered profoundly by contact with extracellular matrix proteins (ECMs). We characterized functional responses (intracellular calcium, actin polymerization, degranulation, adhesion, and oxidative burst) of bovine neutrophils adhered to selected ECM proteins [collagen IV, lam...

journal_title：Journal of leukocyte biology

authors： Borgquist JD,Quinn MT,Swain SD

更新日期：2002-05-01 00:00:00

abstract：:Cytohesin-1 and ARNO are guanine nucleotide-exchange factors (GEFs) for ADP-ribosylation factor (Arf). Here, we show that ARNO is expressed in HL-60 cells and established that granulocytic differentiation induced with Me2SO stimulated cytohesin-1 but not ARNO expression. Cytohesin-1 levels in HL-60 granulocytes were s...

journal_title：Journal of leukocyte biology

authors： Bourgoin SG,Houle MG,Singh IN,Harbour D,Gagnon S,Morris AJ,Brindley DN

更新日期：2002-04-01 00:00:00

abstract：:Glucosamine, an amino monosaccharide naturally occurring in the connective and cartilage tissues, contributes to maintaining the strength, flexibility, and elasticity of these tissues. In recent years, glucosamine has been used widely to treat osteoarthritis in humans and animal models. Neutrophils, which usually func...

journal_title：Journal of leukocyte biology

authors： Hua J,Sakamoto K,Nagaoka I

更新日期：2002-04-01 00:00:00

abstract：:Lymphocyte function-associated antigen (LFA-1) is a member of the beta2 family of integrins that is selectively expressed on leukocytes. Herein, we show that Ca(2)(+) mobilizing agents A23187, thapsigargin, and ionomycin induce an increase in adhesion to the LFA-1 ligand intercellular adhesion molecule-1 (ICAM-1) and ...

journal_title：Journal of leukocyte biology

authors： Rodríguez-Fernández JL,Sánchez-Martín L,de Frutos CA,Sancho D,Robinson M,Sánchez-Madrid F,Cabañas C

更新日期：2002-03-01 00:00:00

abstract：:Hematopoietic cells extend multiple podia of yet unknown function. Our morphological studies using scanning electron microscopy and functional studies using time-lapse video microscopy suggest that podia formed by CD34+ hematopoietic stem cells (HSC) on the bone marrow stroma component fibronectin are characteristic o...

journal_title：Journal of leukocyte biology

authors： Fruehauf S,Srbic K,Seggewiss R,Topaly J,Ho AD

更新日期：2002-03-01 00:00:00

abstract：:M-CSF is a pleiotropic cytokine involved in the survival, proliferation, and differentiation of cells of the monocyte/macrophage lineage. M-CSF is produced by numerous cells including CD3-activated T cells. M-CSF serum levels are increased during acute graft rejection. We tested the in vitro production of M-CSF, GM-CS...

journal_title：Journal of leukocyte biology

authors： Frétier S,Besse A,Delwail A,Garcia M,Morel F,Leprivey-Lorgeot V,Wijdenes J,Praloran V,Lecron JC

更新日期：2002-02-01 00:00:00

abstract：:Previously, we described a novel glycosylphosphatidyl inositol (GPI)-anchored glycoprotein (designated GPI-80) on human neutrophils and monocytes that may regulate beta(2) integrin-dependent neutrophil adherence and migration. However, the mechanism regulating beta(2) integrin remains to be clarified. To study this, w...

journal_title：Journal of leukocyte biology

authors： Yoshitake H,Takeda Y,Nitto T,Sendo F

更新日期：2002-02-01 00:00:00

abstract：:CXC chemokines, which induce angiogenesis, have glutamine-leucine-arginine amino acid residues (ELR motif) in the amino terminus and bind CXCR2 and the Duffy antigen chemokine-binding protein. Duffy, a seven transmembrane protein that binds CXC and CC chemokines, has not been shown to couple to trimeric G proteins or ...

journal_title：Journal of leukocyte biology

authors： Du J,Luan J,Liu H,Daniel TO,Peiper S,Chen TS,Yu Y,Horton LW,Nanney LB,Strieter RM,Richmond A

更新日期：2002-01-01 00:00:00

abstract：:Mast cell activation requires Cl(-) flux, which maintains the driving force for entry of extracellular calcium and initiates release of mediators such as histamine. However, chloride channel expression in mast cells has been poorly understood. For the first time, reverse transcriptase-polymerase chain reaction shows t...

journal_title：Journal of leukocyte biology

authors： Kulka M,Gilchrist M,Duszyk M,Befus AD

更新日期：2002-01-01 00:00:00

abstract：:Potential mechanisms underlying impaired chemotactic responsiveness of neonatal neutrophils were investigated. Two distinct chemoattractants were compared: bacterially derived N-formyl-methionyl-leucyl-phenylalanine (fMLP) and a unique chemotactic monoclonal antibody, designated DL1.2, which binds to a neutrophil anti...

journal_title：Journal of leukocyte biology

authors： Weinberger B,Laskin DL,Mariano TM,Sunil VR,DeCoste CJ,Heck DE,Gardner CR,Laskin JD

更新日期：2001-12-01 00:00:00

abstract：:Elderly humans are more susceptible to bacterial infections because of declining immune status. We have investigated the effect of aging on neutrophil bactericidal responses, comparing neutrophil function in healthy, young (23-35 years) and elderly (>65 years) volunteers. Superoxide generation in response to fMLP was ...

journal_title：Journal of leukocyte biology

authors： Butcher SK,Chahal H,Nayak L,Sinclair A,Henriquez NV,Sapey E,O'Mahony D,Lord JM

更新日期：2001-12-01 00:00:00

abstract：:C1qR(P) is a type I cell surface glycoprotein that has been shown to enhance ingestion of suboptimally opsonized targets by phagocytes in vitro. In this study, we developed and characterized polyclonal antibodies to study the tissue distribution of this receptor targeted to either the N- or C-terminal portion of the m...

journal_title：Journal of leukocyte biology

authors： Fonseca MI,Carpenter PM,Park M,Palmarini G,Nelson EL,Tenner AJ

更新日期：2001-11-01 00:00:00

abstract：:The interaction between CD40 on dendritic cells (DC) and its ligand CD154 has been recognized to be an important feature in the maturation of DC. Here, we were interested in the role of CD44 a surface receptor shown to mediate cell-cell adhesion and binding to Hyaluronic acid (HA). Western blot analysis of human DC st...

journal_title：Journal of leukocyte biology

authors： Termeer C,Johannsen H,Braun T,Renkl A,Ahrens T,Denfeld RW,Lappin MB,Weiss JM,Simon JC

更新日期：2001-11-01 00:00:00

abstract：:The immunosuppressive activity of interleukin-10 (IL-10) makes this cytokine a potentially important clinical tool to reduce inflammatory responses in various diseases. Its efficacy as a therapeutic modality is dependent on the responsiveness of immune cells. We report that macrophages from mice chronically infected w...

journal_title：Journal of leukocyte biology

authors： Avdiushko R,Hongo D,Lake-Bullock H,Kaplan A,Cohen D

更新日期：2001-10-01 00:00:00

abstract：:CEACAM6 (CD66c) and CEACAM8 (CD66b) are cell-adhesion proteins on neutrophils that belong to the human carcinoembryonic antigen (CEA) family. CEACAM6 reveals homophilic adhesion and heterophilic adhesion to other CEACAM family antigens including CEACAM8, CEACAM1, and CEA, whereas CEACAM8 exhibits only heterophilic adh...

journal_title：Journal of leukocyte biology

authors： Kuroki M,Abe H,Imakiirei T,Liao S,Uchida H,Yamauchi Y,Oikawa S,Kuroki M

更新日期：2001-10-01 00:00:00

abstract：:Apoptotic leukocytes undergo cellular changes that are used as markers for "early" versus "late" stages of apoptosis. To ascertain if the order for acquisition of these changes is unique to specific hematopoietic cell types, we compared four leukocyte cell types and the following five apoptotic characteristics: MC540 ...

journal_title：Journal of leukocyte biology

authors： Hess KL,Johnson JD,Cook-Mills JM

更新日期：2001-09-01 00:00:00

abstract：:The viral CC chemokines MC148, encoded by the poxvirus molluscum contagiosum, and viral macrophage inflammatory protein (vMIP)-I and vMIP-II, encoded by human herpesvirus 8, were probed on the murine CC receptor (CCR) 8 in parallel with human CCR8. In calcium mobilization assays, vMIP-I acted as a high-affinity agonis...

journal_title：Journal of leukocyte biology

authors： Lüttichau HR,Gerstoft J,Schwartz TW

更新日期：2001-08-01 00:00:00

abstract：:In vitro studies have suggested that targeting interleukin (IL)-1 and tumor necrosis factor (TNF) can be used to regulate intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) and potentially treat kidney inflammation. We therefore evaluated ICAM-1 and VCAM-1 regulation in knockout ...

journal_title：Journal of leukocyte biology

authors： Burne MJ,Elghandour A,Haq M,Saba SR,Norman J,Condon T,Bennett F,Rabb H

更新日期：2001-08-01 00:00:00

abstract：:Previously, we showed that NO induces thymocyte apoptosis via a caspase-1-dependent mechanism [(1) ]. In the present study, we investigated the role of heme oxygenase, catalase, bax, and p53 in this process. The NO donor, S-nitroso-N-acetyl penicillamine (SNAP), induced DNA fragmentation in thymocytes in a time- and c...

journal_title：Journal of leukocyte biology

authors： Gordon SA,Abou-Jaoude W,Hoffman RA,McCarthy SA,Kim YM,Zhou X,Zhang XR,Simmons RL,Chen Y,Schall L,Ford HR

更新日期：2001-07-01 00:00:00

abstract：:Recent advances have led to the identification and characterization of an array of transmembrane proteases that mediate the proteolysis of various substrates (including bioactive peptides, components of the extracellular matrix, and integral proteins) and cell-cell or cell-matrix adhesion. The membrane proteases known...

journal_title：Journal of leukocyte biology

authors： Bauvois B

更新日期：2001-07-01 00:00:00

abstract：:In this study, we examined the expression of nerve growth factor (NGF) and its receptors in mouse macrophages and the mechanisms involved in the effect of NGF on tumor necrosis factor (TNF)-alpha production. Macrophages expressed NGF and the NGF receptors TrkA and p75. Treatment of J744 cells or peritoneal macrophages...

journal_title：Journal of leukocyte biology

authors： Barouch R,Kazimirsky G,Appel E,Brodie C

更新日期：2001-06-01 00:00:00

abstract：:We studied the tissue distribution of CD6(+) lymphocytes and cells expressing the CD6 ligand (also known as activated leukocyte cell adhesion molecule CD166) in calves by immunohistochemistry using an anti-bovine CD6 monoclonal antibody (mAb), a human CD6 (huCD6)-immunoglobulin G1 fusion protein (huCD6-Ig), and an ant...

journal_title：Journal of leukocyte biology

authors： Konno A,Ahn JS,Kitamura H,Hamilton MJ,Gebe JA,Aruffo A,Davis WC

更新日期：2001-06-01 00:00:00

abstract：:T-cell recognition of foreign antigen and migration to specific anatomic sites in vivo involves transient adhesive contacts between beta1 integrins expressed on T cells and cell surface proteins or extracellular-matrix components. Engagement of the CD3-T-cell receptor (CD3-TCR) complex initiates a complex signaling ca...

journal_title：Journal of leukocyte biology

authors： Woods ML,Shimizu Y

更新日期：2001-06-01 00:00:00

abstract：:To become competent killer cells, CD8(+) T cells require stimulation through signal transduction pathways associated with the T-cell receptor, costimulatory molecules such as CD28, and cytokine receptors such as the interleukin (IL)-2 receptor. We used wortmannin and LY294002, two inhibitors of phosphatidylinositol 3-...

journal_title：Journal of leukocyte biology

authors： Phu T,Haeryfar SM,Musgrave BL,Hoskin DW

更新日期：2001-05-01 00:00:00

abstract：:Polymorphonuclear granulocytes (PMNs) are known to contribute to reperfusion injury of the heart. However, whether PMNs compromise myocardial function of hearts exposed to a low-flow ischemia has not been determined. Moreover, not much is known about deleterious effects of PMNs at different times during ischemia and r...

journal_title：Journal of leukocyte biology

authors： Seligmann C,Bock A,Leitsch T,Schimmer M,Simsek Y,Schultheiss HP

更新日期：2001-05-01 00:00:00

abstract：:Prostaglandin J2 metabolite 15-deoxy-delta(12,14)-prostaglandin J2 (15-PGJ2) appears to possess anti-inflammatory properties. Unlike other prostaglandins, it has no known plasma membrane receptor. Its effects have been thought to occur through activation of the nuclear peroxisome proliferator-activated receptor gamma ...

journal_title：Journal of leukocyte biology

authors： Guyton K,Bond R,Reilly C,Gilkeson G,Halushka P,Cook J

更新日期：2001-04-01 00:00:00

abstract：:We have shown that low-dose UVB radiation converts Langerhans cells (LC) from immunogenic to tolerogenic APC. Therefore, we questioned whether low-dose UVB irradiation of bone marrow-derived dendritic cells (DC) alters their APC function, thereby inducing tolerance in T cells. To address this issue, cocultures of DC; ...

journal_title：Journal of leukocyte biology

authors： Denfeld RW,Hara H,Tesmann JP,Martin S,Simon JC

更新日期：2001-04-01 00:00:00

abstract：:Glucocorticoids (GC) are potent anti-inflammatory and immunosuppressive agents that act on a variety of immune cells, including T cells, monocytes/macrophages, osteoclasts, and dendritic cells (DC). However, the mechanism(s) by which GC exert anti-inflammatory effects is still largely unknown. It is already well known...

journal_title：Journal of leukocyte biology

authors： Kim KD,Choe YK,Choe IS,Lim JS

更新日期：2001-03-01 00:00:00